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KMID : 0359319910310030265
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Korean Journal of Veterinary Research
1991 Volume.31 No. 3 p.265 ~ p.270
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BioEffect of dietary vitamin E on the lipid peroxidation by dietary iron injected to male rats
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허린수/Huh, Rhin Sou
김영홍/도재철/최연식/정정원/Kim, Young Hong/Do, Jae Cheul/Choi, Yeon Shik/Cheong, Cheong Won
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Abstract
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This study was designed to investigate the effect of dietary vitamin E on the lipid peroxidation by dietary iron-injected to male rats.
Sprague-Dawely strain male rats were divided into three experimental groups, namely control, iron Injected and iron-vitamin E injected groups. The control group was fed with normal diet; the iron injected group was given normal diet and wh.ile injected intraperitoneally 30㎎ of ferric hydroxide/100g of body weight 20 times every 3 days. The iron-vitamin E injected group was intraperitoneally administered 30㎎ of ferric hydroxide/100g of body weight 20 times every 3 days and vitamin E every day with the dose of 5IU(5㎎)/100g body weight. All experimental groups were maintained for 60 days with feeding on the respective ratio.
The results obtained from this experiment were summarized as following:
1. The net weight gain was significantly decreased by the iron injection, but much increased by the vitamin E injection.
2. The contents of unsaturated fatty acid in phospholipid in liver, kidney, muscle and serum were decreased by the iron injection, but increased by the vitamin E injection.
3. The increment of malondialdehyde contents was induced by the iron overloading, but significantly decreased by the vitamin E injection.
Therefore, it is suggested that dietary iron administration to male rats facilitates the lipid peroxidation in vivo and vitamin E has the inhibiting effect on lipip peroxidation process by iron.
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KEYWORD
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iron, vitamin E, unsaturated fatty acid, malondialdehyde, lipid peroxidation, antioxidative effect
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